Another of our assets relates to our research into a different form of the SERCA enzyme, SERCA2b. Specifically these SERCA2b enzymes control calcium movement in the endoplasmic reticulum (ER) in all human cells. SERCA2b enzyme levels become deficient when cells are stressed and accumulate unfolded proteins in the ER, known as ER stress. There has been a proliferation of publications in the scientific and medical literature supporting the important role of ER stress in many diseases and conditions, including heart failure, diabetes and neurodegenerative diseases.
Using our proprietary, patented SERCA2 screening assay, we have developed a broad platform of novel, first-in-class, small molecule modulators of the SERCA2b enzyme, which have the potential to correct underlying calcium dysregulation and ER stress. These proprietary compounds have demonstrated activity in several preclinical models of diseases and conditions.